| 产品名称 | NT 157 |
| 产品货号 | Axon 2238 CAS [1384426-12-3] MF C16H14BrNO5SMW 412.26 Purity: 99% Soluble in DMSO Description Unique allosteric inhibitor of IGF1R. NT 157 promotes ERK-MAPK dependent inhibitory Ser-phosphorylation and degradation of insulin receptor substrate 1 and 2 (IRS1/2) by shifting IGF1R complexation from IRS1/2 to Shc, which results in long-term inhibition of IGF1R signaling and powerful inhibition of tumor cell growth. References Certificates Categories Extra info H. Reuveni et al. Therapeutic Destruction of Insulin Receptor Substrates for Cancer Treatment. Cancer Res. 2013, 73, 4383-4394. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology IGF1R Endocrinology MAPK PI3K-Akt-mTOR RTK class II; EC 2.7.10.1 Unique allosteric inhibitor of IGF1R signaling Chemical name (E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide Parent CAS No. [1384426-12-3] Order Size Unit Price Stock 2 mg €95.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
NT 157Axon 2238 CAS [1384426-12-3] MF C16H14BrNO5S
Description
Unique allosteric inhibitor of IGF1R. NT 157 promotes ERK-MAPK dependent inhibitory Ser-phosphorylation and degradation of insulin receptor substrate 1 and 2 (IRS1/2) by shifting IGF1R complexation from IRS1/2 to Shc, which results in long-term inhibition of IGF1R signaling and powerful inhibition of tumor cell growth.
Unique allosteric inhibitor of IGF1R signaling
Chemical name(E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide Parent CAS No.[1384426-12-3] |
| 产品资料 |
