| 产品名称 | LDK 378 - Ceritinib |
| 产品货号 | Axon 2224 CAS [1032900-25-6] MF C28H36ClN5O3SMW 558.14 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Potent, bioavailable, and selective anaplastic lymphoma kinase (ALK) inhibitor (IC50 value 0.2 nM) with >35 fold selectivity over InsR, IGF-1R. LDK 378 induced a dose-dependent tumor growth inhibition and tumor regression in multiple rat xenograft models. References Certificates Categories Extra info J. Chen et al. LDK378: a promising anaplastic lymphoma kinase (ALK) inhibitor. J. Med. Chem. 2013, 56, 5673-5674. T.H. Marsilje et al. Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(...). J. Med. Chem. 2013, 56, 5675-5690. E. Ardini et al. ALK Inhibitors, a Pharmaceutical Perspective. Front Oncol. 2012, 2, 17. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology ALK TGF-β RTK class XIX; 2.7.10.1 Potent, bioavailable, and selective anaplastic lymphoma kinase (ALK) inhibitor Chemical name 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine Parent CAS No. [1032900-25-6] Order Size Unit Price Stock 5 mg €95.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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LDK 378 - CeritinibAxon 2224 CAS [1032900-25-6] MF C28H36ClN5O3S
Description
Potent, bioavailable, and selective anaplastic lymphoma kinase (ALK) inhibitor (IC50 value 0.2 nM) with >35 fold selectivity over InsR, IGF-1R. LDK 378 induced a dose-dependent tumor growth inhibition and tumor regression in multiple rat xenograft models.
Potent, bioavailable, and selective anaplastic lymphoma kinase (ALK) inhibitor
Chemical name5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine Parent CAS No.[1032900-25-6] |
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