产品名称

NVP-TAE684 - TAE 684

产品货号

Axon 1416 CAS [761439-42-3] MF C30H40ClN7O3SMW 614.20 Purity: 99% Soluble in DMSO Description Potent, selective and efficacious inhibitor of NPM-ALK. KEYWORDS: NVP-TAE684 | supplier | ALK inhibitor | TAE 684 | NVPTAE684 | TAE684 | TAE-684 | CAS [761439-42-3] | NPM-ALK | fusion protein | anaplastic large-cell lymphoma | ALCL | apoptosis | cell cycle arrest | nucleophosmin

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

NVP-TAE684 - TAE 684

Based on 356 reference(s) in Google Scholar 9 10 356

Axon 1416

CAS [761439-42-3]

MF C30H40ClN7O3S
MW 614.20

Purity: 99%
Soluble in DMSO

NVP-TAE684

Description

Potent, selective and efficacious inhibitor of NPM-ALK.

KEYWORDS: NVP-TAE684 | supplier | ALK inhibitor | TAE 684 | NVPTAE684 | TAE684 | TAE-684 | CAS [761439-42-3] | NPM-ALK | fusion protein | anaplastic large-cell lymphoma | ALCL | apoptosis | cell cycle arrest | nucleophosmin

AV Galkin et al. Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. Proc. Natl. Acad. Sci. USA 2007, 104 (1), 270-275.

U McDermott et al. Genomic Alterations of Anaplastic Lymphoma Kinase May Sensitize Tumors to Anaplastic Lymphoma Kinase Inhibitors. Cancer Res. 2008, 68(9), 3389-3395.

K van Roosbroeck et al. ALK-positive large B-cell lymphomas with cryptic SEC31A-ALK and NPM1-ALK fusions. Haematologica. 2010, 95, 509-513.

List of publications using NVP-TAE684 (Axon 1416) purchased from Axon Medchem

Cell Signaling & Oncology p53-Tumor Suppression EC 2.7.10.1 ALK ALK

NPM-ALK inhibitor

Chemical name

5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-pyperidinyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-Pyrimidinediamine

Parent CAS No.

[761439-42-3]

产品资料