产品名称 GSK 1120212 - Trametinib | JTP 74057
产品货号 Axon 1761 CAS [871700-17-3] MF C26H23FIN5O4MW 615.39 Purity: 99% Soluble in DMSO Description Highly potent and selective MEK inhibitor, with IC50 values to be 0.7 and 0.9 nM for MEK1 and MEK2 respectively and with long circulating half-life References Certificates Categories Extra info AG Gilmartin et al. GSK1120212 (JTP-74057) is an inhibitor of MEK activity and activation with favorable pharmacokinetic properties for sustained in vivo pathway inhibition. Clin. Cancer Res. 2011, 17(5), 989-1000.   T Yamaguchi et al. Antitumor activities of JTP-74057 (GSK1120212), a novel MEK1/2 inhibitor, on colorectal cancer cell lines in vitro and in vivo. Int J Oncol. 2011, 39(1), 23-31.   H Abe et al. Discovery of a Highly Potent and Selective MEK Inhibitor: GSK1120212 (JTP-74057 DMSO Solvate). ACS Med. Chem. Lett., 2011, 2(4), 320–324. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology MAPK EC 2.7.12.2 MEK MEK1 and MEK2 inhibitor Chemical name N-(3-(3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide Parent CAS No. [871700-17-3] Order Size Unit Price Stock 5 mg €95.00 In Stock
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GSK 1120212 - Trametinib | JTP 74057

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 1761

CAS [871700-17-3]

MF C26H23FIN5O4
MW 615.39

  • Purity: 99%
  • Soluble in DMSO

GSK 1120212

Description

Highly potent and selective MEK inhibitor, with IC50 values to be 0.7 and 0.9 nM for MEK1 and MEK2 respectively and with long circulating half-life
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