产品名称

CD161

产品货号

Axon 2776 CAS [1627716-22-6] MF C26H21N5O2MW 435.48 Purity: 98% Soluble in DMSO Description CD161 is a potent, orally active and selective BET bromodomain inhibitor (Ki values of 8.2 nM and 1.4 nM for BRD4 BD1 and BD2, respectively). CD161 inhibits cell growth in acute leukemia cell lines and breast cancer cell lines. Moreover, CD161 has an excellent oral pharmacokinetic profile and, orally administered, effectively inhibits tumor growth in mice. KEYWORDS: CD161 | supplier | BET inhibitor | CD-161 | CD 161 | CAS [1627716-22-6] | Histone | BET (BRD) | Inhibitor | Proteins | BRD4 | Leukemia | Breast Cancer | Bioavailable

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

CD161

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 2776

CAS [1627716-22-6]

MF C26H21N5O2
MW 435.48

Purity: 98%
Soluble in DMSO

CD161

Description

CD161 is a potent, orally active and selective BET bromodomain inhibitor (Ki values of 8.2 nM and 1.4 nM for BRD4 BD1 and BD2, respectively). CD161 inhibits cell growth in acute leukemia cell lines and breast cancer cell lines. Moreover, CD161 has an excellent oral pharmacokinetic profile and, orally administered, effectively inhibits tumor growth in mice.

Y Zhao et al. Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor. J Med Chem. 2017 May 11;60(9):3887-3901.

Cell Signaling & Oncology Epigenetics BET (BRD)

Potent, selective, and orally active BET bromodomain inhibitor

Chemical name

4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole

Parent CAS No.

[1627716-22-6]

产品资料