| 产品名称 | OF-1 |
| 产品货号 | Axon 2442 CAS [919973-83-4] MF C17H18BrN3O4SMW 440.31 Purity: 99% Soluble in DMSO Description Potent Bromodomain inhibitor with selectivity for BRPF1 and BRPF2 (Kd values 100 nM, 500 nM, and 2.4 μM for BRPF1B, BRPF2, and BRPF3, respectively). Selectivity against other bromodomains is very good, in general >100-fold. The closest off-target effects are against BRD4 (39-fold selectivity) and TIF1a (50% inhibition at 20 µM. OF-1 increases thermal stability in the cellular thermal shift assay (CETSA) of full length BRPF1B at 1 µM and also demonstrates accelerated FRAP recovery at 5 µM in the BRPF2 FRAP assay. KEYWORDS: OF1 | supplier | BRPF inhibitor | OF-1 supplier | CAS [919973-83-4] | Histone | BRPF (BRD) | Inhibitor | SGC | Bromodomain | Chromatin | BRPF1 | BRPF1B | BRPF2 | BRD4 | TIF1a | FRAP | epigenetic | DNA |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
OF-1Axon 2442 CAS [919973-83-4] MF C17H18BrN3O4S
DescriptionPotent Bromodomain inhibitor with selectivity for BRPF1 and BRPF2 (Kd values 100 nM, 500 nM, and 2.4 μM for BRPF1B, BRPF2, and BRPF3, respectively). Selectivity against other bromodomains is very good, in general >100-fold. The closest off-target effects are against BRD4 (39-fold selectivity) and TIF1a (50% inhibition at 20 µM. OF-1 increases thermal stability in the cellular thermal shift assay (CETSA) of full length BRPF1B at 1 µM and also demonstrates accelerated FRAP recovery at 5 µM in the BRPF2 FRAP assay. KEYWORDS: OF1 | supplier | BRPF inhibitor | OF-1 supplier | CAS [919973-83-4] | Histone | BRPF (BRD) | Inhibitor | SGC | Bromodomain | Chromatin | BRPF1 | BRPF1B | BRPF2 | BRD4 | TIF1a | FRAP | epigenetic | DNA
Potent bromodomain inhibitor (BRPF1 and BRPF2 selective)
Chemical name4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methylbenzenesulfonamide Parent CAS No.[919973-83-4] |
| 产品资料 |
