产品名称

NS 11394

产品货号

Axon 1457 CAS [951650-22-9] MF C23H19N3OMW 353.42 Purity: 99% Soluble in DMSO Description A unique subtype-selective GABAA receptor positive allosteric modulator (PAM); with a subtype selectivity profile at GABAA receptors of α5 > α3 > α2 > α1. Compared with other subtype-selective ligands, NS11394 is unique in having superior efficacy at GABAA-α3 receptors while maintaining low efficacy at GABAA-α1 receptors, which might be attributed for its significantly reduced side effect profile in rat. KEYWORDS: NS 11394 | supplier | 951650-22-9 | GABAA PAM | NS11394 | GABA-A | γ-aminobutyric acid | gamma-aminobutyric acid | positive allosteric modulator | agonist

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

NS 11394

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 1457

CAS [951650-22-9]

MF C23H19N3O
MW 353.42

Purity: 99%
Soluble in DMSO

NS 11394

Description

A unique subtype-selective GABAA receptor positive allosteric modulator (PAM); with a subtype selectivity profile at GABAA receptors of α5 > α3 > α2 > α1. Compared with other subtype-selective ligands, NS11394 is unique in having superior efficacy at GABAA-α3 receptors while maintaining low efficacy at GABAA-α1 receptors, which might be attributed for its significantly reduced side effect profile in rat.

NR Mirza et al. NS11394 , a Unique Subtype-Selective GABAA Receptor Positive Allosteric Modulator: In Vitro Actions, Pharmacokinetic Properties and in Vivo Anxiolytic Efficacy. J. Pharmacol. Exp. Ther. 2008, 327, 954-968.

G. Munro et al. Comparison of the Novel Subtype-Selective GABAA Receptor-Positive Allosteric Modulator NS11394 with Diazepam, Zolpidem, Bretazenil, and Gaboxadol in Rat Models of Inflammatory and Neuropathic Pain. J. Ph. Exp. Ther. 2008, 327, 969-981.

PAM of GABAA

Chemical name

3'-[5-(1-Hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile

Parent CAS No.

[951650-22-9]

产品资料