产品名称

TP 003

产品货号

Axon 1422 CAS [628690-75-5] MF C23H16F3N3OMW 407.39 Purity: 99% Soluble in DMSO and Ethanol Description Subtype selective partial agonist at GABAA receptor, showing significant efficacy at α3; nonbenzodiazepine anxiolytic. KEYWORDS: TP 003 | supplier | GABAA-α3 agonist | TP003 | TP-003 | CAS [628690-75-5] | GABA | GABA-A | Ion Channel | receptor | alfa-3 | anxiolytic | non-benzodiazepine | anticonvulsant

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

TP 003

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 1422

CAS [628690-75-5]

MF C23H16F3N3O
MW 407.39

Purity: 99%
Soluble in DMSO and Ethanol

TP 003

Description

Subtype selective partial agonist at GABAA receptor, showing significant efficacy at α3; nonbenzodiazepine anxiolytic.

KEYWORDS: TP 003 | supplier | GABAA-α3 agonist | TP003 | TP-003 | CAS [628690-75-5] | GABA | GABA-A | Ion Channel | receptor | alfa-3 | anxiolytic | non-benzodiazepine | anticonvulsant

R Dias et al. Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines. J. Neurosci. 2005, 25(46), 10682–10688.

RL Fradley et al. Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands. J. Psychopharmacol. 2007, 4, 384-391.

W Sieghart. GABAA receptors as targets for different classes of drugs. Drugs Fut. 2006, 31(8), 685.

J Knabl et al. Reversal of pathological pain through specific spinal GABAAreceptor subtypes. Nature 2008, 451, 330-334.

CNS Pain & Inflammation GABA-A Unclassified

GABAA-α3 agonist

Chemical name

4,2'-difluoro-5'-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazol[1,2-a`]pyridine-3-yl]biphenyl-2-carbonitrile

Parent CAS No.

[628690-75-5]

产品资料