产品名称

Akt Inhibitor VIII - Akti-1/2

产品货号

Axon 2540 CAS [612847-09-3] MF C34H29N7OMW 551.64 Purity: 98% Soluble in 0.1N HCl(aq) and DMSO Description Non-ATP-competitive inhibitor of Akt isoforms 1 and 2 (IC50 values 58 nM and 210 nM for Akt1 and Akt2, respectively). Moreover, the Akt inhibitor efficiently inhibits Ca2+/CaM-dependent protein kinase (CaMKIα) activity (IC50 value 3.99 μM) and prevents TCDD induced nuclear translocation of aryl hydrocarbon receptor (AhR) in MCF-7 cells. Akti-1/2 inhibitory effects towards CaMKIα and TCDD-induced EROD activity in function of Akti-1/2 concentrations were quite similar (IC50 ± SD, 3.99 ± 0.82 μM and 5.86 ± 1.85 μM, respectively). KEYWORDS: Akt Inhibitor VIII | supplier | Akt inhibitor | Akti-1/2 | compound8 | inhibitorVIII | CAS [612847-09-3] | Phosphatidylinositol | Akt | PI3K | PKB | calcium | Ca2+/CaM-dependent protein kinase | CaMKIα | aryl hydrocarbon receptor | AhR | TCDD

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

Akt Inhibitor VIII - Akti-1/2

Based on 16 publications in PubMed 9 10 16

Axon 2540

CAS [612847-09-3]

MF C34H29N7O
MW 551.64

Purity: 98%
Soluble in 0.1N HCl(aq) and DMSO

Akt Inhibitor VIII

Description

Non-ATP-competitive inhibitor of Akt isoforms 1 and 2 (IC50 values 58 nM and 210 nM for Akt1 and Akt2, respectively). Moreover, the Akt inhibitor efficiently inhibits Ca2+/CaM-dependent protein kinase (CaMKIα) activity (IC50 value 3.99 μM) and prevents TCDD induced nuclear translocation of aryl hydrocarbon receptor (AhR) in MCF-7 cells. Akti-1/2 inhibitory effects towards CaMKIα and TCDD-induced EROD activity in function of Akti-1/2 concentrations were quite similar (IC50 ± SD, 3.99 ± 0.82 μM and 5.86 ± 1.85 μM, respectively).

D. Gilot et al. Akti-1/2, an allosteric inhibitor of Akt 1 and 2, efficiently inhibits CaMKIα activity and aryl hydrocarbon receptor pathway. Chem Biol Interact. 2010 Dec 5;188(3):546-52.

C.W. Lindsley et al. Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors. Bioorg Med Chem Lett. 2005 Feb 1;15(3):761-4.

Inhibitor of Akt1 and 2 with significant off-side effects (CaMKIα and AhR)

Chemical name

1-(1-(phenyl-1H-imidazo[4,5-g]quinoxalin-6-yl)benzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

Parent CAS No.

[612847-09-3]

产品资料