产品名称

LY 2584702 tosylate

产品货号

Axon 2464 CAS [1082949-68-5] MF C21H19F4N7.C7H8O3SMW 617.62 Purity: 98% Soluble in DMSO Description Oral, selective ATP-competitive inhibitor of p70 S6 kinase (S6K1; IC50 value 4 nM) with significant synergistic activity with Erlotinib (Axon 1128) and Everolimus. LY2584702 is selective against 83 other kinases as determined by a ubiquitin kinase panel, and 45 cell surface markers as determined by a CEREP mini panel. KEYWORDS: LY 2584702 tosylate | supplier | S6K1 inhibitor | LY 2779964 | LY2584702 | LY2779964 | CAS [1082949-68-5] | [1082949-67-4] | (Ribosomal proteins) | p70-RSK | Inhibitor | p70S6K | PI3K | mTOR | Akt | ribosomal | cancer | Phase I | trial | ATP-competitive

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

LY 2584702 tosylate

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2464

CAS [1082949-68-5]

MF C21H19F4N7.C7H8O3S
MW 617.62

Purity: 98%
Soluble in DMSO

LY 2584702 tosylate

Description

Oral, selective ATP-competitive inhibitor of p70 S6 kinase (S6K1; IC50 value 4 nM) with significant synergistic activity with Erlotinib (Axon 1128) and Everolimus. LY2584702 is selective against 83 other kinases as determined by a ubiquitin kinase panel, and 45 cell surface markers as determined by a CEREP mini panel.

KEYWORDS: LY 2584702 tosylate | supplier | S6K1 inhibitor | LY 2779964 | LY2584702 | LY2779964 | CAS [1082949-68-5] | [1082949-67-4] | (Ribosomal proteins) | p70-RSK | Inhibitor | p70S6K | PI3K | mTOR | Akt | ribosomal | cancer | Phase I | trial | ATP-competitive

A. Hollebecque et al. A phase Ib trial of LY2584702 tosylate, a p70 S6 inhibitor, in combination with erlotinib or everolimus in patients with solid tumours. Eur J Cancer. 2014 Mar;50(5):876-84.

A. Tolcher et al. A phase I trial of LY2584702 tosylate, a p70 S6 kinase inhibitor, in patients with advanced solid tumours. Eur J Cancer. 2014 Mar;50(5):867-75.

H Liu et al. Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia. Cell Reports 2017 Feb. 18(9):2088–2095.

Cell Cycle Regulation Cell Signaling & Oncology MAPK PI3K-Akt-mTOR EC 2.7.11.1 p70-RSK

Oral, selective ATP-competitive inhibitor of p70 S6 kinase (S6K1)

Chemical name

4-(4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazol-2-yl)piperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine 4-methylbenzenesulfonate

Parent CAS No.

[1082949-67-4]

产品资料