产品名称

CM-272

产品货号

Axon 2812 CAS [1846570-31-7] MF C28H38N4O3MW 478.63 Purity: 98% Soluble in 0.1N HCl(aq) and DMSO Recently added

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

CM-272

Based on 4 reference(s) in Google Scholar 8 10 4

Axon 2812

CAS [1846570-31-7]

MF C28H38N4O3
MW 478.63

Purity: 98%
Soluble in 0.1N HCl(aq) and DMSO

Recently added

CM-272

Description

CM-272 is a first-in-class potent, selective and reversible inhibitor of histone methyltransferase G9a and DNA-methyltransferase 1 with IC50 values of 8nM and 382 nM, respectively. CM-272 inhibits cell proliferation and promotes apoptosis, inducing interferon-stimulated genes and immunogenic cell death. Moreover, CM-272 significantly prolongs survival of AML, ALL and DLBCL xenogeneic models.

KEYWORDS: CM-272 | suppplier | G9a/DNMT inhibitor | CM272 | CM 272 | CAS [1846570-31-7] | CAS [1846570-32-8] | Histone | HMTase | Inhibitor | Enzymes | Haematological tumour | Haematological neoplasia | Hepatocellular carcinoma

E San José-Enériz et al. Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies. Nat Commun. 2017 May 26;8:15424.

E Rabal O, San José-Enériz et al. Discovery of Reversible DNA Methyltransferase and Lysine Methyltransferase G9a Inhibitors with Antitumoral in Vivo Efficacy. J Med Chem. 2018 Aug 9;61(15):6518-6545.

JA Rabal O, Sánchez-Arias et al. Detailed Exploration around 4-Aminoquinolines Chemical Space to Navigate the Lysine Methyltransferase G9a and DNA Methyltransferase Biological Spaces. J Med Chem. 2018 Aug 9;61(15):6546-6573.

M Bárcena-Varela et al. Dual Targeting of Histone Methyltransferase G9a and DNA-Methyltransferase 1 for the Treatment of Experimental Hepatocellular Carcinoma. Hepatology. 2019 Feb;69(2):587-603.

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Epigenetics Stem Cell EC 2.1.1.37 EC 2.1.1.43 DNA methyltransferase HMTase

First-in-class potent, selective and reversible inhibitor of G9a/DNMT

Chemical name

6-Methoxy-2-(5-methylfuran-2-yl)-N-(1-methylpiperidin-4-yl)-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-amine

Parent CAS No.

[1846570-31-7]

产品资料