| 产品名称 | GSK 2110183 hydrochloride - Afuresertib hydrochloride |
| 产品货号 | Axon 2460 CAS [1047645-82-8] MF C18H17Cl2FN4OS.HClMW 463.78 Purity: 99% Optical purity: Optically pure Soluble in water and DMSO Description Potent, reversible, selective, and orally bioavailable inhibitor of the Akt kinases (Ki values 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively), with some inhibitory effect on PKA and PKG1a. GSK2110183 preferentially inhibits the proliferation of human cancer cell lines with Akt pathway activation, and various cell lines derived from hematologic malignancies, in an ATP-competitive manner and with a minimal effect on glucose homeostasis. References Certificates Categories Extra info M. Dumble et al. Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor. PLoS One. 2014 Jun 30;9(6):e100880. A. Spencer et al. The novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma. Blood. 2014 Oct 2;124(14):2190-5. Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology Akt PI3K-Akt-mTOR EC 2.7.11.1 Potent, reversible, selective, and orally bioavailable inhibitor of the Akt kinases Chemical name N-((S)-1-amino-3-(3-fluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxamide hydrochloride Parent CAS No. [1047644-62-1] Order Size Unit Price Stock 5 mg €105.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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GSK 2110183 hydrochloride - Afuresertib hydrochlorideAxon 2460 CAS [1047645-82-8] MF C18H17Cl2FN4OS.HCl
Description
Potent, reversible, selective, and orally bioavailable inhibitor of the Akt kinases (Ki values 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively), with some inhibitory effect on PKA and PKG1a. GSK2110183 preferentially inhibits the proliferation of human cancer cell lines with Akt pathway activation, and various cell lines derived from hematologic malignancies, in an ATP-competitive manner and with a minimal effect on glucose homeostasis.
Potent, reversible, selective, and orally bioavailable inhibitor of the Akt kinases
Chemical nameN-((S)-1-amino-3-(3-fluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxamide hydrochloride Parent CAS No.[1047644-62-1] |
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