| 产品名称 | UNC 0379 |
| 产品货号 | Axon 2418 CAS [1620401-82-2] MF C23H35N5O2MW 413.56 Purity: 98% Soluble in DMSO Description Substrate competitive inhibitor of the H4K20 HMTase SETD8 (IC50 value 7.3 µM) with selectivity over 15 other methyltransferases including G9a and GLP. MOA studies revealed that UNC0379 is noncompetitive with the cofactor S-adenosyl-Lmethionine (SAM). References Certificates Categories Extra info A. Ma et al. Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. J Med Chem. 2014 Aug 14;57(15):6822-33. J. Min et al. L3MBTL1 recognition of mono- and dimethylated histones. Nat Struct Mol Biol. 2007 Dec;14(12):1229-30. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Epigenetics p53-Tumor Suppression DNA-damage Response EC 2.1.1.43 HMTase Substrate competitive inhibitor of the H4K20 HMTase SETD8 Chemical name 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine Parent CAS No. [1620401-82-2] Order Size Unit Price Stock 10 mg €125.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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UNC 0379Axon 2418 CAS [1620401-82-2] MF C23H35N5O2
Description
Substrate competitive inhibitor of the H4K20 HMTase SETD8 (IC50 value 7.3 µM) with selectivity over 15 other methyltransferases including G9a and GLP. MOA studies revealed that UNC0379 is noncompetitive with the cofactor S-adenosyl-Lmethionine (SAM).
Substrate competitive inhibitor of the H4K20 HMTase SETD8
Chemical name6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine Parent CAS No.[1620401-82-2] |
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