产品名称

FMK - RSK inhibitor Fmk

产品货号

Axon 1848 CAS [821794-92-7] MF C18H19FN4O2MW 342.37 Purity: 99% Soluble in DMSO Description Potent, highly specific and irreversible inhibitor of p90 ribosomal protein S6 kinase RSK1 and RSK2; FMK binds in the CTKD ATP-binding site and inhibits RSK autophosphorylation at Ser386. FMK induces significant apoptosis in human FGFR3-expressing, t(4;14)-positive multiple myeloma cells.* FMK (IC50 value 15 nM for RSK2 in vitro) is more potent than another CTKD RSK inhibitor SL-0101 (IC50 value 85 nM for RSK2); while BI-D1870 (Axon 1528) binds at NTKD binding site as a reversible RSK inhibitor. References Certificates Categories Extra info MS Cohen et al. Structural bioinformatics-based design of selective, irreversible kinase inhibitors. Science 2005, 308(5726),1318–1321. S Kang et al. p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells. J. Clin. Invest. 2010, 120(4), 1165–1177. Doehn et al. RSK Is a Principal Effector of the RAS-ERK Pathway for Eliciting a Coordinate Promotile/Invasive Gene Program and Phenotype in Epithelial Cells. Mol. Cell, 2009, 35(4), 511–522. TL Nguyen. Targeting RSK: an overview of small molecule inhibitors. Anticancer Agents Med. Chem. 2008, 8(7), 710-716. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology MAPK PI3K-Akt-mTOR EC 2.7.11.1 p90-RSK RSK inhibitor (p90 RSK specific) Chemical name 1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-fluoroethanone Parent CAS No. [821794-92-7] Order Size Unit Price Stock 1 mg €75.00 In Stock

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axonmedchem

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FMK - RSK inhibitor Fmk

Based on 90 reference(s) in Google Scholar 9 10 90

Axon 1848

CAS [821794-92-7]

MF C18H19FN4O2
MW 342.37

Purity: 99%
Soluble in DMSO

FMK

Description

Potent, highly specific and irreversible inhibitor of p90 ribosomal protein S6 kinase RSK1 and RSK2; FMK binds in the CTKD ATP-binding site and inhibits RSK autophosphorylation at Ser386. FMK induces significant apoptosis in human FGFR3-expressing, t(4;14)-positive multiple myeloma cells.
* FMK (IC50 value 15 nM for RSK2 in vitro) is more potent than another CTKD RSK inhibitor SL-0101 (IC50 value 85 nM for RSK2); while BI-D1870 (Axon 1528) binds at NTKD binding site as a reversible RSK inhibitor.