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产品名称 EPZ 6438 - Tazemetostat
产品货号 Axon 2227 CAS [1403254-99-8] MF C34H44N4O4MW 572.74 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Potent, selective, and orally bioavailable inhibitor of EZH2 enzymatic activity (IC50 values 2-38 nM in EZH2 assays). Induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells, and dose-dependently leads to regression of malignant rhabdoid tumors (MRTs) with correlative diminution of intratumoral trimethylation levels of H3K27, and prevention of tumor regrowth after dosing cessation. References Certificates Categories Extra info S.K. Knutson et al. Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2. Proc. Natl. Acad. Sci. USA. 2013, 110, 7922-7927.  Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Epigenetics EC 2.1.1.43 Stem Cell Differentiator HMTase Inhibitor of Histone Lysine Methyltransferase EZH2 Chemical name N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)biphenyl-3-carboxamide Parent CAS No. [1403254-99-8] Order Size Unit Price Stock 5 mg €105.00 In Stock
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EPZ 6438 - Tazemetostat

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2227

CAS [1403254-99-8]

MF C34H44N4O4
MW 572.74

  • Purity: 99%
  • Soluble in 0.1N HCl(aq) and DMSO

EPZ 6438

Description

Potent, selective, and orally bioavailable inhibitor of EZH2 enzymatic activity (IC50 values 2-38 nM in EZH2 assays). Induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells, and dose-dependently leads to regression of malignant rhabdoid tumors (MRTs) with correlative diminution of intratumoral trimethylation levels of H3K27, and prevention of tumor regrowth after dosing cessation.
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