| 产品名称 | PRMT3 inhibitor 1 - Compound 1 |
| 产品货号 | Axon 2211 CAS [1340875-03-7] MF C15H18N4OSMW 302.39 Purity: 99% Soluble in DMSO Description Allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3; IC50 value of 1.6 μM for inhibition of full length PRMT3 in a radioactivity-based assay). PRMT3 inhibitor 1 showed no inhibitory activity on any of the PKMTs G9a, EHMT1, SUV39H2, SETD7, and SETD8, and PRMTs PRMT1, PRMT4, PRMT5, and PRMT8.The allosteric binding site of compound 1 was localized by site-directed mutagenesis of PRMT3 and X-ray crystallography. References Certificates Categories Extra info A. Siarheyeva et al. An allosteric inhibitor of protein arginine methyltransferase 3. Structure. 2012, 20, 1425-1435. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Epigenetics Endocrinology EC 2.1.1.125 PRMT Allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) Chemical name 1-(benzo[d][1,2,3]thiadiazol-6-yl)-3-(2-cyclohexenylethyl)urea Parent CAS No. [1340875-03-7] Order Size Unit Price Stock 5 mg €105.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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PRMT3 inhibitor 1 - Compound 1Axon 2211 CAS [1340875-03-7] MF C15H18N4OS
Description
Allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3; IC50 value of 1.6 μM for inhibition of full length PRMT3 in a radioactivity-based assay). PRMT3 inhibitor 1 showed no inhibitory activity on any of the PKMTs G9a, EHMT1, SUV39H2, SETD7, and SETD8, and PRMTs PRMT1, PRMT4, PRMT5, and PRMT8.The allosteric binding site of compound 1 was localized by site-directed mutagenesis of PRMT3 and X-ray crystallography.
Allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3)
Chemical name1-(benzo[d][1,2,3]thiadiazol-6-yl)-3-(2-cyclohexenylethyl)urea Parent CAS No.[1340875-03-7] |
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