产品名称

TM 5441

产品货号

Axon 2734 CAS [1190221-43-2] MF C21H17ClN2O6MW 428.82 Purity: 99% Soluble in 0.1N NaOH(aq) and DMSO Description TM5441 is an orally active PAI-1 inhibitor, which protects mice against L-NAME–induced vascular pathologies, including hypertension, fibrosis, and vascular senescence. TM5441 is a derivative of PAI-1 inhibitor TM5275 (Axon 2344), however showed better pharmacokinetics and volume of distribution. KEYWORDS: TM 5441 | supplier | PAI-1 inhibitor | TM-5441 | TM5441 | CAS [1190221-43-2] | Serpin | Plasminogen activator inhibitor-1 (PAI-1) | Inhibitor | Enzymes | L-NAME

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

TM 5441

Based on 8 reference(s) in Google Scholar 8 10 8

Axon 2734

CAS [1190221-43-2]

MF C21H17ClN2O6
MW 428.82

Purity: 99%
Soluble in 0.1N NaOH(aq) and DMSO

TM 5441

Description

TM5441 is an orally active PAI-1 inhibitor, which protects mice against L-NAME–induced vascular pathologies, including hypertension, fibrosis, and vascular senescence. TM5441 is a derivative of PAI-1 inhibitor TM5275 (Axon 2344), however showed better pharmacokinetics and volume of distribution.

AE Boe et al. Plasminogen activator inhibitor-1 antagonist TM5441 attenuates Nω-nitro-L-arginine methyl ester-induced hypertension and vascular senescence. Circulation. 2013 Nov 19;128(21):2318-24.

VR Placencio et al. Small Molecule Inhibitors of Plasminogen Activator Inhibitor-1 Elicit Anti-Tumorigenic and Anti-Angiogenic Activity. PLoS One. 2015 Jul 24;10(7):e0133786.

Cardiovascular Cell Cycle Regulation Cell Signaling & Oncology Miscellaneous Plasminogen activator inhibitor-1 (PAI-1) EC 3.4.21.68

Orally active inhibitor of PAI-1

Chemical name

5-Chloro-2-(2-(2-(3-(furan-3-yl)phenylamino)-2-oxoethoxy)acetamido)benzoic acid

Parent CAS No.

[1190221-43-2]

产品资料