| 产品名称 | E 5555 hydrobromide - Atopaxar hydrobromide |
| 产品货号 | Axon 2030 CAS [474550-69-1] MF C29H38FN3O5.HBrMW 608.54 Purity: 99% Soluble in DMSO Description Potent and orally active thrombin receptor (or protease-activated receptor 1, PAR1) antagonist (IC50: 19 nM); E5555 showed potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC50 values of 64 and 31nM, respectively References Certificates Categories Extra info LV Serebruany et al. The in-vitro effects of E5555, a protease-activated receptor (PAR)-1 antagonist, on platelet biomarkers in healthy volunteers and patients with coronary artery disease. Thromb. Haemost. 2009, 102(1), 111-119. S Goto et al. Double-blind, placebo-controlled Phase II studies of the protease-activated receptor 1 antagonist E5555 (atopaxar) in Japanese patients with acute coronary syndrome or high-risk coronary (...). Eur. Heart J. 2010, 31(21), 2601-2613. M Kogushi et al. The novel and orally active thrombin receptor antagonist E5555 (Atopaxar) inhibits arterial thrombosis without affecting bleeding time in guinea pigs. Eur. J. Pharmacol. 2011, 657(1-3), 131-137. Y Kai et al. Prevention of the hypercontractile response to thrombin by proteinase-activated receptor-1 antagonist in subarachnoid hemorrhage. Stroke. 2007 Dec;38(12):3259-65. Certificate of Analysis Material Safety Data Sheet Cardiovascular Cell Signaling & Oncology A15 Thrombin (PAR) Potent and orally active PAR1 antagonist Chemical name 1-(3-tert-butyl-4-methoxy-5-morpholinophenyl)-2-(5,6-diethoxy-7-fluoro-1-iminoisoindolin-2-yl)ethanone hydrobromide Parent CAS No. [751475-53-3] Order Size Unit Price Stock 2 mg €115.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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E 5555 hydrobromide - Atopaxar hydrobromideAxon 2030 CAS [474550-69-1] MF C29H38FN3O5.HBr
Description
Potent and orally active thrombin receptor (or protease-activated receptor 1, PAR1) antagonist (IC50: 19 nM); E5555 showed potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC50 values of 64 and 31nM, respectively
Potent and orally active PAR1 antagonist
Chemical name1-(3-tert-butyl-4-methoxy-5-morpholinophenyl)-2-(5,6-diethoxy-7-fluoro-1-iminoisoindolin-2-yl)ethanone hydrobromide Parent CAS No.[751475-53-3] |
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