产品名称

AM 36 dihydrochloride - CNSB002

产品货号

Axon 1113 CAS [199467-52-2] MF C27H39ClN2O2.2HClMW 531.99 Purity: 98% Moderately soluble in water Description Na+ channel blocker; neuroprotective agent. KEYWORDS: AM 36 dihydrochloride | supplier | Na+ channel Blocker | CNSB002 | AM36 |CAS[199467-52-2] | Sodium | Blocker | Ion Channels | Nav1.3 | Nav1.7 | Nav1.8 | neuropathic pain | analgesic | neuroprotective |ROS

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

AM 36 dihydrochloride - CNSB002

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 1113

CAS [199467-52-2]

MF C27H39ClN2O2.2HCl
MW 531.99

Purity: 98%
Moderately soluble in water

AM 36 dihydrochloride

Description

Na+ channel blocker; neuroprotective agent.

KEYWORDS: AM 36 dihydrochloride | supplier | Na+ channel Blocker | CNSB002 | AM36 |CAS[199467-52-2] | Sodium | Blocker | Ion Channels | Nav1.3 | Nav1.7 | Nav1.8 | neuropathic pain | analgesic | neuroprotective |ROS

J. K. Callaway et al. Delayed Treatment With AM-36, a Novel Neuroprotective Agent, Reduces Neuronal Damage After Endothelin-1–Induced Middle Cerebral Artery Occlusion in Conscious Rats. Stroke. 1999, 30, 2704-2712.

J. K Callaway et al. Incorporation of sodium channel blocking and free radical scavenging activities into a single drug, AM-36, results in profound inhibition of neuronal apoptosis. Br. J. Pharmacol. 2001, 132, 1691–1698.

A. Kolosov et al. Studies of synergy between morphine and a novel sodium channel blocker, CNSB002, in rat models of inflammatory and neuropathic pain. Pain Med. 2010 Jan;11(1):106-18.

CNS Pain & Inflammation Nav1.7 Unclassified Nav1.2 Nav1.3

Na+ channel blocker

Chemical name

2,6-Di-tert-butyl-4-{4-[2-(4-chloro-phenyl)-2-hydroxy-ethyl]-piperazin-1-ylmethyl}-phenol dihydrochloride

Parent CAS No.

[199467-52-2]

产品资料