SB 277011A - SB 277011 dihydrochloride

Based on 134 publications in PubMed 10 10 134

Axon 1920

CAS [1226917-67-4]

MF C28H30N4O.2HCl
MW 511.49

Purity: 99%
Soluble in water and DMSO

SB 277011A

Description

Potent, selective and brain penetrating D3 dopamine receptor antagonist; with high affinity for the hD3 receptor (pKi = 7.95) and 100-fold selectivity over the hD2 receptor and over 66 other receptors.

G Stemp et al. Design and synthesis of trans-N-[4-[2-(6-cyano-1,2,3, 4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): A potent and selective dopamine D(3) receptor antagonist (...). J. Med. Chem. 2000, 43(9), 1878-1885.

C Reavill et al. Pharmacological actions of a novel, high-affinity, and selective human dopamine D(3) receptor antagonist, SB-277011-A. J. Pharmacol. Exp. Ther. 2000, 294(3), 1154-1165.

E Southam et al. Effect of the selective dopamine D3 receptor antagonist SB-277011-A on regional c-Fos-like expression in rat forebrain. Brain Res. 2007, 1149, 50-57.

CNS D3 A17

D3 dopamine receptor antagonist

Chemical name

N-((trans)-4-(2-(6-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)quinoline-4-carboxamide dihydrochloride

Parent CAS No.

[215803-78-4]

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