PHNO hydrochloride, (+)- - Naxagolide | Dopazinol

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 1071

CAS [99705-65-4]

MF C15H21NO2.HCl
MW 283.79

Purity: 99%
Optical purity: >98% ee
Soluble in water and DMSO

PHNO hydrochloride, (+)-

Description

Very potent and selective D2 agonist, more active enantiomer. Note: Appropriate chiral precursor(s) for making D2 radiotracer, [11C]-(+)-PHNO, can be provided on request.

Martin et al. Selectivity of (+)-4-propyl-9-hydroxynaphthoxazine [(+)-PHNO] for dopamine receptors in vitro and in vivo. J. Pharmacol. Exp. Ther. 1985, 233, 2, 395-401.

N Ginovart et al. Binding characteristics and sensitivity to endogenous dopamine of [11C]-(+)-PHNO, a new agonist radiotracer for imaging the high-affinity state of D2 receptors in vivo using positron emission tomography. J. Neurochem. 2006, 97, 1089-1103

P Seeman et al. Dopamine receptors labelled by PHNO. Synapse. 1993, 14(4), 254-62.

A Graff-Guerrero et al. The effect of antipsychotics on the high-affinity state of D2 and D3 receptors: a positron emission tomography study With [11C]-(+)-PHNO. Arch Gen Psychiatry. 2009, 66(6), 606-15.

CNS D2 A17

D2 agonist

Chemical name

(4aR,10bR)-4-Propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol hydrochloride

Parent CAS No.

[88058-88-2]

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