产品名称

AR7 - Atypical retinoid 7

产品货号

Axon 2679 CAS [80306-38-3] MF C15H12ClNOMW 257.71 Purity: 99,7% Soluble in DMSO Description Atypical RARα receptor antagonist that stimulates CMA (chaperone-mediated autophagy) activity without detectable changes in other autophagic pathways, making cells more resistant to oxidative stress and proteotoxicity. AR7 is also known as a hypoxia targeted compound for cancer therapeutics (IC50 value 10 μM for inhibition of hypoxic cancer cell growth (MTT assay) in HepG2 cells while sparing ‘normoxic’ cells). KEYWORDS: AR7 | supplier | RARα antagonist | Atypical retinoid 7 | AR-7 | AR 7 | CAS [80306-38-3] | Retinoic Acid | nuclear receptor | NR1B1 | chaperone-mediated | autophagy | CMA | hypoxia | cancer | neurodegenerative

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

AR7 - Atypical retinoid 7

Based on 4 reference(s) in Google Scholar 9 10 4

Axon 2679

CAS [80306-38-3]

MF C15H12ClNO
MW 257.71

Purity: 99,7%
Soluble in DMSO

AR7

Description

Atypical RARα receptor antagonist that stimulates CMA (chaperone-mediated autophagy) activity without detectable changes in other autophagic pathways, making cells more resistant to oxidative stress and proteotoxicity. AR7 is also known as a hypoxia targeted compound for cancer therapeutics (IC50 value 10 μM for inhibition of hypoxic cancer cell growth (MTT assay) in HepG2 cells while sparing ‘normoxic’ cells).

BC Das et al. Design, synthesis and biological evaluation of 2H-benzo[b][1,4] oxazine derivatives as hypoxia targeted compounds for cancer therapeutics. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4204-6.

J Anguiano et al. Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives. Nat Chem Biol. 2013 Jun;9(6):374-82.

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology CNS Retinoic Acid (RAR) NR1B Autophagy

RARα antagonist that stimulates chaperone-mediated autophagy

Chemical name

7-chloro-3-p-tolyl-2H-benzo[b][1,4]oxazine

Parent CAS No.

[80306-38-3]

产品资料