产品名称

DU125530

产品货号

Axon 2750 CAS [161611-99-0] MF C23H26ClN3O5SMW 491.99 Purity: 99% Soluble in DMSO Description DU125530 is a selective 5-HT1A receptor antagonist (Ki value of 0.7 nM). DU-125530 showed equal (low nM) potency to displace agonist and antagonist binding to pre- and post-synaptic 5-HT1A receptors in rat and human brain. KEYWORDS: DU125530 | supplier | 5-HT1A antagonist | DU 125530 | DU-125530 | CAS [161611-99-0] | Serotonin | 5-HT1A | Antagonist | Receptors

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

DU125530

Based on 6 reference(s) in Google Scholar 8 10 6

Axon 2750

CAS [161611-99-0]

MF C23H26ClN3O5S
MW 491.99

Purity: 99%
Soluble in DMSO

DU125530

Description

DU125530 is a selective 5-HT1A receptor antagonist (Ki value of 0.7 nM). DU-125530 showed equal (low nM) potency to displace agonist and antagonist binding to pre- and post-synaptic 5-HT1A receptors in rat and human brain.

J Mos et al. The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons. Eur J Pharmacol. 1997 May 1;325(2-3):145-53.

MC Scorza et al. Preclinical and clinical characterization of the selective 5-HT(1A) receptor antagonist DU-125530 for antidepressant treatment. Br J Pharmacol. 2012 Nov;167(5):1021-34.

CNS 5-HT1A A19

5-HT1A antagonist

Chemical name

2-[4-[4-(7-Chloro-2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3(2H)-one-1,1-dioxide

Parent CAS No.

[161611-99-0]

产品资料