产品名称

Stem Cell 2i inhibitor Set

产品货号

Axon 2128 CAS [N.A.] MF N.A.MW N.A. Purity: 99% Soluble in DMSO Description A convenient set of MEK inhibitor PD 0325901 (Axon 1408) and GSK3 inhibitor CHIR 99021 (Axon 1386); highly recommended conventional 2i inhibitor set, used together for dual inhibition of MAPK signaling and GSK-3 in stem cell research, to enable mouse embryonic stem cell (mESC) self-renewal and pluripotency marker expression. Prime Source Information

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axonmedchem

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Stem Cell 2i inhibitor Set

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2128

CAS [N.A.]

MF N.A.
MW N.A.

Purity: 99%
Soluble in DMSO

Stem Cell 2i inhibitor Set

Description

A convenient set of MEK inhibitor PD 0325901 (Axon 1408) and GSK3 inhibitor CHIR 99021 (Axon 1386); highly recommended conventional 2i inhibitor set, used together for dual inhibition of MAPK signaling and GSK-3 in stem cell research, to enable mouse embryonic stem cell (mESC) self-renewal and pluripotency marker expression.

Prime Source Information:
CHIR 99021 and PD 0325901 from Axon Medchem have been procured by many labs as drug standards for generating reliable and reproducible biological data, evidenced by many recent publications. They are highly pure drugs to be perfect 2i in stem cell research. Be right about your drugs!

Read more: Additional Product Information

Show all Axon Ligand™ Sets

O. Gafni et al. Derivation of novel human ground state naive pluripotent stem cells. Nature 2013, 504, 282-286.

A.A. Mansour et al. The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming. Nature. 2012, 488, 409-413.

C. Tong et al. Generating gene knockout rats by homologous recombination in embryonic stem cells. Nature Protocols 2011, 6, 827-844.

M. Kawamata et al. Generation of genetically modified rats from embryonic stem cells. Proc. Natl. Acad. Sci. USA. 2010, 107, 14223-14228.

M.Y. Chang et al. Direct reprogramming of rat neural precursor cells and fibroblasts into pluripotent stem cells. PLoS One. 2010, 5, e9838.

Q.L.Ying et al. The ground state of embryonic stem cell self-renewal. Nature. 2008, 453, 519-523.

List of publications using CHIR 99021 (Axon 1386) purchased from Axon Medchem

List of publications using PD 0325901 (Axon 1408) purchased from Axon Medchem

Cell Signaling & Oncology CNS Diabetes & Metabolism Immunology Pain & Inflammation Stem Cell GSK-3 Wnt-β-Catenin MAPK PI3K-Akt-mTOR Stem Cells MEK Pfizer Licensed Products

Set of MEK inhibitor PD0325901 (Axon 1408) and GSK-3 inhibitor CHIR99021 (Axon 1386)

Chemical name

N.A.

Source information

Pfizer compound; Sold for research purposes under agreement from Pfizer Inc.

Parent CAS No.

[N.A.]

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