产品名称

LDN 193189 hydrochloride - DM 3189 hydrochloride

产品货号

Axon 1509 CAS [1435934-00-1] MF C25H22N6.2HClMW 479.40 Purity: 99% Soluble in water and DMSO Description A highly potent small molecule BMP inhibitor; inhibiting BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation; useful tool in stem cell biology. LDN 193189 shows significant in vivo clinical utility, inhibiting FOP and ectopic ossification and a potential agent in the treatment of NSCLC lung tumors. *Promotion

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

LDN 193189 hydrochloride - DM 3189 hydrochloride

Based on 77 publications in PubMed 10 10 77

Axon 1509

CAS [1435934-00-1]

MF C25H22N6.2HCl
MW 479.40

Purity: 99%
Soluble in water and DMSO

LDN 193189 hydrochloride

Description

A highly potent small molecule BMP inhibitor; inhibiting BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation; useful tool in stem cell biology. LDN 193189 shows significant in vivo clinical utility, inhibiting FOP and ectopic ossification and a potential agent in the treatment of NSCLC lung tumors.

*Promotion: LDN 193189 HCl is also part of Inhibitor Set(s):

Axon 5004

Axon 5005

Axon 5007

Prime Source Information:
The molecule of LDN 193189 contains multiple basic nitrogens, which could form 1-4 eq HCl salt of LDN 193189. This ligand from Axon is the best quality drug standard and its accurate salt form has been determined by microanalysis and specified on the certificate of analysis (COA) of every batch.

KEYWORDS: LDN 193189 hydrochloride | supplier | BMP inhibitor | DM 3189 HCl | LDN193189 | DM3189 | CAS [1435934-00-1] | [1062368-24-4] | [1062368-62-0] | TGF-β | BMP-ALK | Antagonist | RSTK | ALK2 | ALK3 | ALK6 | SMAD | stem cell biology | FOP | ectopic ossification | NSCLC