产品名称

DAPT

产品货号

Axon 1484 CAS [208255-80-5] MF C23H26F2N2O4MW 432.46 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Inhibitor of γ-secretase. *Promotion

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

DAPT

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 1484

CAS [208255-80-5]

MF C23H26F2N2O4
MW 432.46

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

DAPT

Description

Inhibitor of γ-secretase.

*Promotion: DAPT is also part of Inhibitor Set(s):

Axon 5006

Axon 5007

J Kanungo et al. The Notch signaling inhibitor DAPT down-regulates cdk5 activity and modulates the distribution of neuronal cytoskeletal proteins. J. Neurochem. 2008, 106, 2236-2248.

TQ Crawford, H Roelink. The notch response inhibitor DAPT enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independently of sonic hedgehog signaling. Dev Dyn. 2007, 236(3), 886-92.

TV Arumugam et al. Gamma secretase–mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke. Nature Medicine 2006, 12, 621-623.

CA Micchelli et al. γ-Secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila. FASEB J. 2003, 17, 79-81.

γ-Secretase inhibitor

Chemical name

(S)-{(S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-propionylamino}-phenyl-acetic acid tert-butyl ester

Parent CAS No.

[208255-80-5]

产品资料