产品名称

VU6001221

产品货号

Axon 2670 CAS [2002495-17-0] MF C20H26ClN3O3MW 391.89 Purity: 98% Soluble in DMSO Description VU6001221 is a choline transporter (CHT) inhibitor (IC50 value of 270 nM) with comparable potency for choline uptake inhibition as ML352 (Axon 2587), yet improved PK and CNS penetration. For the first time, VU6001221 allowed evaluation of a CHT inhibitor in a standard preclinical rodent cognition model, namely novel object recognition (NOR). KEYWORDS: VU6001221 | CHT inhibitor | VU 6001221 | VU-6001221 | CAS [2002495-17-0] | Choline | CHT | Inhibitor | Proteins

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

VU6001221

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 2670

CAS [2002495-17-0]

MF C20H26ClN3O3
MW 391.89

Purity: 98%
Soluble in DMSO

VU6001221

Description

VU6001221 is a choline transporter (CHT) inhibitor (IC50 value of 270 nM) with comparable potency for choline uptake inhibition as ML352 (Axon 2587), yet improved PK and CNS penetration. For the first time, VU6001221 allowed evaluation of a CHT inhibitor in a standard preclinical rodent cognition model, namely novel object recognition (NOR).

KEYWORDS: VU6001221 | CHT inhibitor | VU 6001221 | VU-6001221 | CAS [2002495-17-0] | Choline | CHT | Inhibitor | Proteins

JL Bertron et al. Optimization of the choline transporter (CHT) inhibitor ML352: Development of VU6001221, an improved in vivo tool compound. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4637-40.

CNS CHT

Choline transporter inhibitor

Chemical name

4-Chloro-N-((3-isopropylisoxazol-5-yl)methyl)-3-(1-methylpiperidin-4-yloxy)benzamide

Parent CAS No.

[2002495-17-0]

产品资料