产品名称

SU11652

产品货号

Axon 2767 CAS [326914-10-7] MF C22H27ClN4O2MW 414.93 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description SU11652 is a sunitinib-like RTK inhibitor of PDGFR-β, VEGFR2, FGFR1 and FLT3, with IC50 values of 3, 27, 170 and 1.5 nM, respectively. Moreover, SU11652 inhibits cKit, acid sphingomyelinase, destabilizes lysosomes, and inhibits multidrug resistance. KEYWORDS: SU11652 | supplier | RTK inhibitor | SU 11652 | SU-11652 | CAS [326914-10-7] | SCF-PDGF-VEGF | c-KIT | PDGFR | VEGFR | FLT3 | Inhibitor | Receptors | Acid sphingomyelinase

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

SU11652

Based on 18 reference(s) in Google Scholar 8 10 18

Axon 2767

CAS [326914-10-7]

MF C22H27ClN4O2
MW 414.93

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

SU11652

Description

SU11652 is a sunitinib-like RTK inhibitor of PDGFR-β, VEGFR2, FGFR1 and FLT3, with IC50 values of 3, 27, 170 and 1.5 nM, respectively. Moreover, SU11652 inhibits cKit, acid sphingomyelinase, destabilizes lysosomes, and inhibits multidrug resistance.

KEYWORDS: SU11652 | supplier | RTK inhibitor | SU 11652 | SU-11652 | CAS [326914-10-7] | SCF-PDGF-VEGF | c-KIT | PDGFR | VEGFR | FLT3 | Inhibitor | Receptors | Acid sphingomyelinase

AT Liao et al. Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors. Blood. 2002 Jul 15;100(2):585-93.

L Sun et al. Discovery of 5-[5-fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2003 Mar 27;46(7):1116-9.

Y Guo et al. SU11652 Inhibits tyrosine kinase activity of FLT3 and growth of MV-4-11 cells. J Hematol Oncol. 2012 Dec 6;5:72.

AM Ellegaard et al. Sunitinib and SU11652 inhibit acid sphingomyelinase, destabilize lysosomes, and inhibit multidrug resistance. Mol Cancer Ther. 2013 Oct;12(10):2018-30.

Angiogenesis Cell Signaling & Oncology FLT3 VEGFR PDGFR c-KIT RTK class III and IV; EC 2.7.10.1

Multi-targeted receptor tyrosine kinase inhibitor

Chemical name

(Z)-5-((5-chloro-2-oxoindolin-3-ylidene)methyl)-N-(2-(diethylamino)ethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide

Parent CAS No.

[326914-10-7]

产品资料