产品名称

Apatinib - Apatinib mesylate | YN968D1 | Rivoceranib mesylate

产品货号

Axon 2849 CAS [1218779-75-9] MF C25H27N5O4SMW 493.58 Purity: 99% Soluble in DMSO Description Potent and selective inhibitor of VEGFR2 tyrosine kinase (IC50 value of 1 nM). Apatinib could also potently suppress the activities of RET, c-KIT and c-Src with IC50 values of 0.13, 0.429 and 0.53 μM, respectively. In vivo, apatinib alone and in combination with chemotherapeutic agents effectively inhibited the growth of several established human tumor xenograft models with little toxicity. KEYWORDS: Apatinib | supplier | VEGFR2 inhibitor | Apatinib mesylate | YN968D1 | Rivoceranib mesylate | CAS [1218779-75-9] | [811803-05-1] | VEGF | VEGFR | Inhibitor | Receptors | Angiogenesis

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

Apatinib - Apatinib mesylate | YN968D1 | Rivoceranib mesylate

Based on 70 reference(s) in Google Scholar 8 10 70

Axon 2849

CAS [1218779-75-9]

MF C25H27N5O4S
MW 493.58

Purity: 99%
Soluble in DMSO

Apatinib

Description

Potent and selective inhibitor of VEGFR2 tyrosine kinase (IC50 value of 1 nM). Apatinib could also potently suppress the activities of RET, c-KIT and c-Src with IC50 values of 0.13, 0.429 and 0.53 μM, respectively. In vivo, apatinib alone and in combination with chemotherapeutic agents effectively inhibited the growth of several established human tumor xenograft models with little toxicity.

S Tian et al. YN968D1 is a novel and selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase with potent activity in vitro and in vivo. Cancer Sci. 2011 Jul;102(7):1374-80.

Angiogenesis Cell Signaling & Oncology VEGFR RTK class IV; EC 2.7.10.1

Inhibitor of VEGFR2

Chemical name

N-(4-(1-cyanocyclopentyl)phenyl)-2-(pyridin-4-ylmethylamino)nicotinamide mesylate

Parent CAS No.

[811803-05-1]

产品资料