| 产品名称 | AST 1306 tosylate |
| 产品货号 | Axon 1986 CAS [1050500-29-2] MF C24H18ClFN4O2.C7H8O3SMW 621.08 Purity: 98% Soluble in DMSO Description A selective, irreversible ErbB2 and EGFR inhibitor whose growth-inhibitory effects are more potent in ErbB2-overexpressing cells; AST1306 potently inhibits wild-type EGFR and ErbB2, as well as EGFR mutant T790M/L858R, in both cell-free and intact cell assays; IC50 values to be 0.5, 3.0, 0.8 and 12 nM for EGFR, ErbB2, ErbB4 and EGFR mutant T790M/L858R, respectively References Certificates Categories Extra info H Xie et al. AST1306, A Novel Irreversible Inhibitor of the Epidermal Growth Factor Receptor 1 and 2, Exhibits Antitumor Activity Both In Vitro and In Vivo. PLoS ONE 2011, 6(7), e21487. Certificate of Analysis Material Safety Data Sheet Angiogenesis Cell Signaling & Oncology EGFR ErbB2-HER2 JAK-STAT RTK class I; EC 2.7.10.1 ErbB2 and EGFR inhibitor Chemical name N-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)acrylamide 4-methylbenzenesulfonate Parent CAS No. [897383-62-9] Order Size Unit Price Stock 5 mg €105.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
| 产品概述 | |
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AST 1306 tosylateAxon 1986 CAS [1050500-29-2] MF C24H18ClFN4O2.C7H8O3S
Description
A selective, irreversible ErbB2 and EGFR inhibitor whose growth-inhibitory effects are more potent in ErbB2-overexpressing cells; AST1306 potently inhibits wild-type EGFR and ErbB2, as well as EGFR mutant T790M/L858R, in both cell-free and intact cell assays; IC50 values to be 0.5, 3.0, 0.8 and 12 nM for EGFR, ErbB2, ErbB4 and EGFR mutant T790M/L858R, respectively
ErbB2 and EGFR inhibitor
Chemical nameN-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)acrylamide 4-methylbenzenesulfonate Parent CAS No.[897383-62-9] |
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