联系方式：400-650-8506
CNEN
产品名称 BMS 540215 - Brivanib
产品货号 Axon 1850 CAS [649735-46-6] MF C19H19FN4O3MW 370.38 Purity: 98% Optical purity: Optically pure Soluble in DMSO Description Potent and ATP-competitive inhibitor of VEGF; it inhibits VEGFR2, -1 and -3 with IC50 of 25, 380 and 10 nM respectively; also showed good selectivity for FGFR-1, -2, and -3 with IC50 of 148, 125 and 68 nM. BMS 540215 is the active component of its prodrug, Brivalib alaninate (BMS 582664, Axon 1864), which hydrolyzes to BMS 540215 in vivo quickly References Certificates Categories Extra info RS Bhide et al. Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor. J. Med. Chem. 2006, 49(7), 2143-2146.    ZW Cai et al. Discovery of brivanib alaninate ((S)-((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), a novel prodrug of dual vascular (...). J. Med. Chem. 2008, 51(6), 1976-1980.    H Huynh et al. Brivanib Alaninate, a Dual Inhibitor of Vascular Endothelial Growth Factor Receptor and Fibroblast Growth Factor Receptor Tyrosine Kinases, Induces Growth Inhibition in Mouse Models (...). Clin. Cancer Res. 2008, 14, 6146.  Certificate of Analysis Material Safety Data Sheet Angiogenesis Cell Signaling & Oncology VEGFR RTK class IV; EC 2.7.10.1 Inhibitor of VEGFR (subtype 2 and 3 selective) Chemical name (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yloxy)propan-2-ol Parent CAS No. [649735-46-6] Order Size Unit Price Stock 5 mg €110.00 In Stock
产品价格 现货询价，电话：010-67529703
产品规格
产品品牌 axonmedchem
产品概述
产品详情

BMS 540215 - Brivanib

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 1850

CAS [649735-46-6]

MF C19H19FN4O3
MW 370.38

  • Purity: 98%
  • Optical purity: Optically pure
  • Soluble in DMSO

BMS 540215

Description

Potent and ATP-competitive inhibitor of VEGF; it inhibits VEGFR2, -1 and -3 with IC50 of 25, 380 and 10 nM respectively; also showed good selectivity for FGFR-1, -2, and -3 with IC50 of 148, 125 and 68 nM. BMS 540215 is the active component of its prodrug, Brivalib alaninate (BMS 582664, Axon 1864), which hydrolyzes to BMS 540215 in vivo quickly
产品资料