产品名称

EGFR Inhibitor [879127-07-8] - EGFR Inhibitor 324674

产品货号

Axon 1760 CAS [879127-07-8] MF C21H18F3N5OMW 413.40 Purity: 99% Soluble in DMSO Description A potent, cell permeable, irreversible and highly selective EGFR tyrosine kinase inhibitor with IC50 value in the nM range References Certificates Categories Extra info Q Zhang et al. Discovery of EGFR selective 4,6-disubstituted pyrimidines from a combinatorial kinase-directed heterocycle library. J. Am. Chem. Soc. 2006, 128(7), 2182-2183. K Okamoto et al. Role of survivin in EGFR inhibitor-induced apoptosis in non-small cell lung cancers positive for EGFR mutations. Cancer Res. 2010, 70(24), 10402-10410. Z Yu et al. Novel irreversible EGFR tyrosine kinase inhibitor 324674 sensitizes human colon carcinoma HT29 and SW480 cells to apoptosis by blocking the EGFR pathway. Biochem. Biophys. Res. Commun. 2011, 411(4), 751-756. Certificate of Analysis Material Safety Data Sheet Angiogenesis Cell Signaling & Oncology EGFR JAK-STAT RTK class I; EC 2.7.10.1 Highly selective EGFR tyrosine kinase inhibitor Chemical name N-(3-(6-(3-(trifluoromethyl)phenylamino)pyrimidin-4-ylamino)phenyl)cyclopropanecarboxamide Parent CAS No. [879127-07-8] Order Size Unit Price Stock 5 mg €125.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

EGFR Inhibitor [879127-07-8] - EGFR Inhibitor 324674

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 1760

CAS [879127-07-8]

MF C21H18F3N5O
MW 413.40

Purity: 99%
Soluble in DMSO

EGFR Inhibitor [879127-07-8]

Description

A potent, cell permeable, irreversible and highly selective EGFR tyrosine kinase inhibitor with IC50 value in the nM range

Q Zhang et al. Discovery of EGFR selective 4,6-disubstituted pyrimidines from a combinatorial kinase-directed heterocycle library. J. Am. Chem. Soc. 2006, 128(7), 2182-2183.

K Okamoto et al. Role of survivin in EGFR inhibitor-induced apoptosis in non-small cell lung cancers positive for EGFR mutations. Cancer Res. 2010, 70(24), 10402-10410.

Z Yu et al. Novel irreversible EGFR tyrosine kinase inhibitor 324674 sensitizes human colon carcinoma HT29 and SW480 cells to apoptosis by blocking the EGFR pathway. Biochem. Biophys. Res. Commun. 2011, 411(4), 751-756.

Angiogenesis Cell Signaling & Oncology EGFR JAK-STAT RTK class I; EC 2.7.10.1

Highly selective EGFR tyrosine kinase inhibitor

Chemical name

N-(3-(6-(3-(trifluoromethyl)phenylamino)pyrimidin-4-ylamino)phenyl)cyclopropanecarboxamide

Parent CAS No.

[879127-07-8]

产品资料