产品名称

EAI045

产品货号

Axon 2680 CAS [1942114-09-1] MF C19H14FN3O3SMW 383.40 Purity: 99% Soluble in DMSO Description EAI045 is an allosteric inhibitor that targets drug-resistant L858R/T790M-mutant EGFR tyrosine kinase (IC50 value of 3 nM), and spares the wild-type receptor (~1000-fold selectivity versus wild-type EGFR at 1 mM ATP). KEYWORDS: EAI045 | supplier | Allosteric EGFR L858R/T790M inhibitor | EAI 045 | EAI-045 | CAS [1942114-09-1] | EGF | EGFR | Inhibitor | Receptors

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

EAI045

Based on 1 reference(s) in Google Scholar 9 10 1

Axon 2680

CAS [1942114-09-1]

MF C19H14FN3O3S
MW 383.40

Purity: 99%
Soluble in DMSO

EAI045

Description

EAI045 is an allosteric inhibitor that targets drug-resistant L858R/T790M-mutant EGFR tyrosine kinase (IC50 value of 3 nM), and spares the wild-type receptor (~1000-fold selectivity versus wild-type EGFR at 1 mM ATP).

Y Jia et al. Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors. Nature. 2016 Jun 2;534(7605):129-32.

Cell Signaling & Oncology EGFR JAK-STAT RTK class I; EC 2.7.10.1

Allosteric EGFR inhibitor (L858R/T790M-specific)

Chemical name

2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide

Parent CAS No.

[1942114-09-1]

产品资料