| 产品名称 | Defactinib - VS 6063 | PF 04554878 |
| 产品货号 | Axon 2574 CAS [1073154-85-4] MF C20H21F3N8O3SMW 510.49 Purity: 98% Soluble in DMSO Description Orally available second-generation inhibitor of focal adhesion kinase (FAK) and proline-rich tyrosine kinase-2 (PYK2) with an acceptable safety profile in clinical trials (IC50 values 0.6 nM for each kinase, and >100-fold greater selectivity for FAK and PYK2 than for other, non-target kinases). Structurally closely related to PF 431396 (Axon 2107). KEYWORDS: Defactinib | supplier | FAK/PYK2 inhibitor | VS 6063 | PF 04554878 | PF04554878 | VS6063 | PF4554878 | CAS [1073154-85-4] | [1073160-26-5] | Phosphorylation | FAK | PYK2 | Inhibitor | focal adhesion kinase | proline-rich tyrosine kinase-2 | solid | tumor | malignancies | prostate cancer |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
Defactinib - VS 6063 | PF 04554878Axon 2574 CAS [1073154-85-4] MF C20H21F3N8O3S
DescriptionOrally available second-generation inhibitor of focal adhesion kinase (FAK) and proline-rich tyrosine kinase-2 (PYK2) with an acceptable safety profile in clinical trials (IC50 values 0.6 nM for each kinase, and >100-fold greater selectivity for FAK and PYK2 than for other, non-target kinases). Structurally closely related to PF 431396 (Axon 2107). KEYWORDS: Defactinib | supplier | FAK/PYK2 inhibitor | VS 6063 | PF 04554878 | PF04554878 | VS6063 | PF4554878 | CAS [1073154-85-4] | [1073160-26-5] | Phosphorylation | FAK | PYK2 | Inhibitor | focal adhesion kinase | proline-rich tyrosine kinase-2 | solid | tumor | malignancies | prostate cancer
Orally available second generation inhibitor of FAK and PYK2
Chemical nameN-methyl-4-(4-((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)benzamide Parent CAS No.[1073154-85-4] |
| 产品资料 |
