产品名称

4μ8C

产品货号

Axon 1902 CAS [14003-96-4] MF C11H8O4MW 204.18 Purity: 99% Soluble in DMSO Description Potent and selective IRE1 α inhibitor (IC50: 60 nM). 4μ8C blocks substrate access to the active site of IRE1 and selectively inactivates both Xbp1 splicing and IRE1-mediated mRNA degradation. KEYWORDS: 4μ8C | Supplier | 14003-96-4 | Axon 1902 | 4mu8C | 4u8C | IRE1 inhibitor | Axon Medchem | Axon1902 | IRE1α | splicing | RNA degradation

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

4μ8C

Based on 47 publications in PubMed 10 10 47

Axon 1902

CAS [14003-96-4]

MF C11H8O4
MW 204.18

Purity: 99%
Soluble in DMSO

4μ8C

Description

Potent and selective IRE1 α inhibitor (IC50: 60 nM). 4μ8C blocks substrate access to the active site of IRE1 and selectively inactivates both Xbp1 splicing and IRE1-mediated mRNA degradation.

KEYWORDS: 4μ8C | Supplier | 14003-96-4 | Axon 1902 | 4mu8C | 4u8C | IRE1 inhibitor | Axon Medchem | Axon1902 | IRE1α | splicing | RNA degradation

BC Cross et al. The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc. Natl. Acad. Sci. USA. 2012, 109(15), E869-78.

Apoptosis Cell Signaling & Oncology EC 2.7.11.1 IRE

IRE1α inhibitor

Chemical name

7-hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde

Parent CAS No.

[14003-96-4]

产品资料