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产品名称 AX-024 hydrochloride | T cell receptor inhibitor | AX024 hydrochloride | AX 024 hydrochloride | AX-024 | AX024 | AX 024 | CAS [1704801-24-0] - [1370544-73-2] | Axon 2692 | Axon Ligand™ with >99% purity available from stock from supplier Axon Medchem
产品货号 Axon 2692 CAS [1704801-24-0] MF C21H22FNO2.HClMW 375.86 Purity: 99% Soluble in water and DMSO Description First-in-class inhibitor of T cell receptor (TCR); AX-024 is an orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC50 value 1 nM). By modulating TCR signaling, the inhibitor prevented the development of psoriasis and asthma and, furthermore, exerted a long-lasting therapeutic effect in a model of autoimmune encephalomyelitis. KEYWORDS: AX-024 hydrochloride | supplier | T cell receptor inhibitor | AX024 hydrochloride | AX 024 hydrochloride | AX-024 | AX024 | AX 024 | Ax24 | CAS [1704801-24-0] | [1370544-73-2] | Antigen | T cell | Inhibitor | Receptors | TCR | Autoimmune | Nck | TCR-Nck | Psoriasis | Asthma | Encephalomyelitis
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AX-024 hydrochloride

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 2692

CAS [1704801-24-0]

MF C21H22FNO2.HCl
MW 375.86

  • Purity: 99%
  • Soluble in water and DMSO

AX-024 hydrochloride

Description

First-in-class inhibitor of T cell receptor (TCR); AX-024 is an orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC50 value 1 nM). By modulating TCR signaling, the inhibitor prevented the development of psoriasis and asthma and, furthermore, exerted a long-lasting therapeutic effect in a model of autoimmune encephalomyelitis.

KEYWORDS: AX-024 hydrochloride | supplier | T cell receptor inhibitor | AX024 hydrochloride | AX 024 hydrochloride | AX-024 | AX024 | AX 024 | Ax24 | CAS [1704801-24-0] | [1370544-73-2] | Antigen | T cell | Inhibitor | Receptors | TCR | Autoimmune | Nck | TCR-Nck | Psoriasis | Asthma | Encephalomyelitis
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