产品名称 | RTA 408 | NRF2 acitivator | Omaveloxolone | RTA408 | CAS [1474034-05-3] | Axon 2497 | Axon Ligand™ with >98% purity available from stock from supplier Axon Medchem |
产品货号 | Axon 2497 CAS [1474034-05-3] MF C33H44F2N2O3MW 554.71 Purity: 98% Optical purity: Optically pure Soluble in DMSO Description Synthetic triterpenoid that potently activates the antioxidative transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) and inhibits the proinflammatory transcription factor NF-κB at low concentrations. RTA 408 dose-dependently reduced NO concentrations (IC50 value 4.4 Nm). At higher concentrations, RTA 408 inhibited tumor cell growth (GI50 value 260 nM) and increased caspase activity in tumor cell lines and is a highly effective mitigator of steady state hematopoiesis. KEYWORDS: RTA 408 | NRF2 acitivator | Axon 2497 | Omaveloxolone | RTA408 | CAS [1474034-05-3] | DNA-RNA | NRF | Activator | Transcription Factor | NF-E2L2 | ROS | NO | nuclear factor erythroid 2-related factor 2 | JNK | NF-κB | inflammatory | radiation | mitigator | hematopoiesis |
产品价格 | 现货询价,电话:010-67529703 |
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产品品牌 | axonmedchem |
产品概述 | |
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RTA 408 - OmaveloxoloneAxon 2497 CAS [1474034-05-3] MF C33H44F2N2O3
DescriptionSynthetic triterpenoid that potently activates the antioxidative transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) and inhibits the proinflammatory transcription factor NF-κB at low concentrations. RTA 408 dose-dependently reduced NO concentrations (IC50 value 4.4 Nm). At higher concentrations, RTA 408 inhibited tumor cell growth (GI50 value 260 nM) and increased caspase activity in tumor cell lines and is a highly effective mitigator of steady state hematopoiesis. KEYWORDS: RTA 408 | NRF2 acitivator | Axon 2497 | Omaveloxolone | RTA408 | CAS [1474034-05-3] | DNA-RNA | NRF | Activator | Transcription Factor | NF-E2L2 | ROS | NO | nuclear factor erythroid 2-related factor 2 | JNK | NF-κB | inflammatory | radiation | mitigator | hematopoiesis
Triterpenoid activator of NRF2 and inhibitor of NF-κB
Chemical nameN-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide Parent CAS No.[1474034-05-3] |
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