产品名称 | ML334 | NRF2 acitivator | LH601A | ML-334 | LH-601A | CAS [1432500-66-7] | Axon 2641 | Axon Ligand™ with >99% purity available from stock from supplier Axon Medchem |
产品货号 | Axon 2641 CAS [1432500-66-7] MF C26H26N2O5MW 446.50 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Activator of NRF2 signaling by inhibition of Keap1-NRF2 protein-protein interaction (PPI; IC50 value 1.6 - 2.3 µM in a fluorescence polarisation assay using Keap1 Kelch domain/NRF2-ETGE peptide; Kd value 1 μM to Keap1 Kelch domain). ML 334 stimulates NRF2 expression and nuclear translocation, and induces antioxidant response elements (ARE) and transcription of HO-1 and TRX1 proteins. KEYWORDS: ML 334 | supplier | NRF2 acitivator | LH 601A | ML334 | LH601A | ML-334 | LH-601A | CAS [1432500-66-7] | DNA-RNA | NRF | Keap | Transcription Factor | Keap1-NRF2 | protein-protein interaction | Neurodegenerative | PPI | Kelch domain | expression | translocation | antioxidant response elements | HO-1 | TRX1 |
产品价格 | 现货询价,电话:010-67529703 |
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产品品牌 | axonmedchem |
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ML334 - LH601AAxon 2641 CAS [1432500-66-7] MF C26H26N2O5
DescriptionActivator of NRF2 signaling by inhibition of Keap1-NRF2 protein-protein interaction (PPI; IC50 value 1.6 - 2.3 µM in a fluorescence polarisation assay using Keap1 Kelch domain/NRF2-ETGE peptide; Kd value 1 μM to Keap1 Kelch domain). ML 334 stimulates NRF2 expression and nuclear translocation, and induces antioxidant response elements (ARE) and transcription of HO-1 and TRX1 proteins. KEYWORDS: ML 334 | supplier | NRF2 acitivator | LH 601A | ML334 | LH601A | ML-334 | LH-601A | CAS [1432500-66-7] | DNA-RNA | NRF | Keap | Transcription Factor | Keap1-NRF2 | protein-protein interaction | Neurodegenerative | PPI | Kelch domain | expression | translocation | antioxidant response elements | HO-1 | TRX1
Activator of NRF2 by inhibition of Keap1-NRF2 interactions
Chemical name(1S,2R)-2-((S)-1-((1,3-dioxoisoindolin-2-yl)methyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)cyclohexanecarboxylic acid Parent CAS No.[1432500-66-7] |
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