产品名称 | JSH 23 | NF-κB inhibitor | JSH23 | CAS [749886-87-1] | Axon 2349 | Axon Ligand™ with >99% purity available from stock from supplier Axon Medchem |
产品货号 | Axon 2349 CAS [749886-87-1] MF C16H20N2MW 240.34 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Inhibitor of NF-κB transcription and nuclear translocation of p65 (IC50 value 7.1 µM for inhibition of LPS-induced NF-κB transcriptional activity) without affecting IκBα degradation, which is a very rare mode of action. JSH 23 inhibited not only LPS-induced expressions of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 and inducible nitric oxide synthase and cyclooxygenase-2 but also LPS-induced apoptosis of the RAW 264.7 cells. JSF 23 also inhibits NO production in LPS-stimulated macrophages RAW 264.7 (IC50 value 14.4 µM). KEYWORDS: JSH 23 | supplier | NF-κB inhibitor | JSH23 | CAS [749886-87-1] | NF-κB | Inhibitor | p65 | IκB | inflammation | transcription factor | Pro-inflammatory | cytokine | LPS | IKK | RAW 264.7 | COX-2 |
产品价格 | 现货询价,电话:010-67529703 |
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产品品牌 | axonmedchem |
产品概述 | |
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JSH 23Axon 2349 CAS [749886-87-1] MF C16H20N2
DescriptionInhibitor of NF-κB transcription and nuclear translocation of p65 (IC50 value 7.1 µM for inhibition of LPS-induced NF-κB transcriptional activity) without affecting IκBα degradation, which is a very rare mode of action. JSH 23 inhibited not only LPS-induced expressions of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 and inducible nitric oxide synthase and cyclooxygenase-2 but also LPS-induced apoptosis of the RAW 264.7 cells. KEYWORDS: JSH 23 | supplier | NF-κB inhibitor | JSH23 | CAS [749886-87-1] | NF-κB | Inhibitor | p65 | IκB | inflammation | transcription factor | Pro-inflammatory | cytokine | LPS | IKK | RAW 264.7 | COX-2
Inhibitor of NF-κB transcription and nuclear translocation of p65 without affecting IκBα degradation
Chemical name4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine Parent CAS No.[749886-87-1] |
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