REL Antibody is a Rabbit Polyclonal antibody against REL. Transcription factors of the nuclear factor κ B (NF-κB)/Rel family play a pivotal role in inflammatory and immune responsesThere are five family members in mammals: RelA, c-Rel, RelB, NF-κB1 (p105/p50), and NF-κB2 (p100/p52)Both p105 and p100 are proteolytically processed by the proteasome to produce p50 and p52, respectivelyRel proteins bind p50 and p52 to form dimeric complexes that bind DNA and regulate transcriptionIn unstimulated cells, NF-κB is sequestered in the cytoplasm by IκB inhibitory proteinsNF-κB-activating agents can induce the phosphorylation of IκB proteins, targeting them for rapid degradation through the ubiquitin-proteasome pathway and releasing NF-κB to enter the nucleus where it regulates gene expressionNIK and IKKα (IKK1) regulate the phosphorylation and processing of NF-κB2 (p100) to produce p52, which translocates to the nucleusThis protein is involved in Transcription.
| Target |
REL |
| Reactivity |
Human, Mouse, Rat |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Tested Applications |
ELISA, WB, IHC |
| Recommended dilutions |
WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Recombinant protein of human REL. |
| Purification |
Affinity Chromatography. |
| Form |
Liquid |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Swiss Prot |
Q04864
|
| GeneID |
5966
|
| Gene Symbol |
REL |
| Buffer |
PBS, pH7.3, containing 0.02% sodium azide and 50% Glycerol. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |