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| Product Name | Active Recombinant Human BMP-7 |
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| Description | Human recombinant protein expressed in Nicotiana benthamiana. It is produced by transient expression in non-transgenic plants. This product contains no animal-derived components or impurities. Animal Free product. The bone morphogenetic proteins are a family of secreted signalling molecules that can induce ectopic bone growth. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extra skeletal site. Bone morphogenetic protein 7 (BMP7), also known as osteogenic protein 1 (OP1), is a widely expressed TGFb superfamily member with important functions during embryogenesis, in the adult, and in disease (Chen et al., 2004, Kishigami and Mishina 2005). BMP7 plays a role in a variety of organ systems. It promotes new bone formation and nephron development (Sampath et al., 1992, Kazama et al., 2008), inhibits the branching of prostate epithelium (Grishina et al., 2005), and antagonizes epithelial-mesenchymal transition (EMT) (Zeisberg et al., 2003, Yu et al., 2009).In pathological conditions, BMP7 inhibits tumour growth and metastasis (Buijs et al., 2007), ameliorates fibrotic damage in nephritis (Zeisberg et al., 2003), and promotes neuroregeneration following brain ischemia (Chou et al., 2006). Recombinant human BMP 7 is a protein composed of 16.5 kDa single chain, containing 144 amino residues. Purity >97% by SDS-PAGE gel |
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| Size | 1 µg, 5 µg, 10 µg, 20 µg, 100 µg |
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| Concentration | n/a |
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| Applications | Functional studies, Cell culture, Western Blot. |
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| Other Names | Osteogenic protein 1 |
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| Gene, Accession, CAS # | UniProt: P18075 |
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| Catalog # | RF0027 |
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| Order / More Info | Active Recombinant Human BMP-7 from AGRENVEC |
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| Product Specific References | - Chen D, Zhao M, Mundy GR: Bone morphogenetic proteins. Growth Factors 22:233-241, 2004. - Kishigami S. and Mishina Y. 2005. BMP signalling and early embryonic patterning. Cytokine Growth Factor Rev. 16: 265-278. - T K Sampath, J C Maliakal, P V Hauschka, W K Jones, H Sasak, R F Tucker, K H White, J E Coughlin, M M Tucker and R H Pang (1992). Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro. J. Biol. Chem. 267:20352. - Kazama I, Mahoney ZX, Miner JH, Graf D, Economides AN, KreidbergJA. Podocyte-specific deletion of BMP7 leads to growth defect of nephrons with inactivation of P38MAPK. J Am Soc Nephrol 19: 2181-2191, 2008. - Grishina IB, Kim SY, Ferrara C, Makarenkova HP, Walden PD. BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signalling. Dev Biol. 2005;288:334-347 - Zeisberg M, Hanai J, Sugimoto H, Mammoto T, Charytan D, Strutz F, Kalluri R. BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat. Med. 9:964-968, 2003 - Buijs JT, Rentsch CA, van der Horst G, van Overveld PG, Wetterwald A, Schwaninger R, Henriquez NV, Dijke P, Borovecki F and Markwalder R. BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo . Am J Pathol . 2007;171:1047-1057 - Yu MA, Shin KS, Kim JH, Kim YI, Chung SS, Park SH, Kim YL, Kang DH: HGF and BMP-7 ameliorate high glucose-induced epithelial-to-mesenchymal transition of peritoneal mesothelium. J Am Soc Nephrol 20: 567-581, 2009 - Chou J, Harvey BK, Chang CF, Shen H, Morales M, Wang Y (2006) Neuroregenerative effects of BMP7 after stroke in rats. J Neurol Sci 240:21-29. |
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