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| Product Name | Mouse ICAD Synthetic Peptide |
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| Description | Mouse ICAD Synthetic Peptide. ICAD is the inhibitor of caspase-3-activated DNase which is a substrate that controls nuclear apoptosis. ICAD has two isoforms: a functional isoform of 45kDa, ICAD-L/DNA fragmentation factor (DFF) 45; and a 35kDa isoform, ICAD-S/DFF35. Although both ICAD-L and ICAD-S can bind and inhibit CAD, only ICAD-L was reported to be functional. ICAD is cleaved to be inactivated and allow caspase-activated DNase (CAD) to execute nuclear internucleosomal apoptotic DNA fragmentation. In non-apoptotic cells, CAD is complexed with its inhibitor, ICAD. The activation of the CAD/ICAD complex occurs through the caspase 3-mediated cleavage of ICAD at residues 117 and 224, which results in three ICAD fragments that are then releas |
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| Size | 50 ug |
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| Concentration | n/a |
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| Applications | Blocking Assay: Assay Dependent, Control: Assay Dependent |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Entrez: 13347; Uniprot: O54786 |
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| Catalog # | PEP-0017 |
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| Order / More Info | Mouse ICAD Synthetic Peptide from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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