| 产品详情 |
| Edit |   |
|---|
| Product Name | Human PUMA Synthetic Peptide |
|---|
| Description | Human PUMA Synthetic Peptide. PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway. |
|---|
| Size | 50 ug |
|---|
| Concentration | n/a |
|---|
| Applications | Blocking Assay: Assay Dependent, Control: Assay Dependent |
|---|
| Other Names | n/a |
|---|
| Gene, Accession, CAS # | Entrez: 27113; Uniprot: Q96PG8 |
|---|
| Catalog # | PEP-0127 |
|---|
| Price | |
|---|
| Order / More Info | Human PUMA Synthetic Peptide from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|