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| Product Name | Human PUMA Synthetic Peptide |
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| Description | Human PUMA Synthetic Peptide. PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway. |
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| Size | 50 ug |
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| Concentration | n/a |
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| Applications | Blocking Assay: Assay Dependent, Control: Assay Dependent |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Entrez: 27113; Uniprot: Q96PG8 |
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| Catalog # | PEP-0128 |
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| Order / More Info | Human PUMA Synthetic Peptide from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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