| 产品详情 |
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| Antigenic Specificity | SOS1 |
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| Clone | SOS-1 |
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| Host Species | Mouse |
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| Reactive Species | rabbit, mouse, guinea pig, bovine, rat, porcine, horse, human, monkey |
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| Isotype | IgG1 |
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| Format | Protein A purified |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | ELISA, IF, WB (1 µg/ml) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | SOS1 Antibody (clone SOS-1) LS-C188432. Recognizes SOS1 (son of sevenless homolog 1), a ubiquitously expressed 150kD intracellular protein and bifunctional guanine nucleotide exchange factor (GEF), which plays a role in growth and differentiation signalling pathways and in actin reorganization, by acting as a regulator of Ras and Rac/Rho GTPases. Mutations in the SOS1 gene are responsible for the rare oral overgrowth condition known as gingival fibromatosis 1 (GINGF1), and also the cause of the relatively common autosomal dominant disorder Noonan syndrome type 4 (NS4), characterized by short stature, congenital heart malformation, bleeding diathesis and distinctive facial features. |
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| Immunogen | Synthetic peptide corresponding to amino acids THPSMHRDGPPLLENAHSS of human SOS1. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Galago, Marmoset, Mouse, Rat, Ferret, Elephant, Panda, Bovine, Cat, Horse, Rabbit, Opossum, Guinea pig (100%); Dog, Turkey, Zebra finch (95%); Lizard (89%). |
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| Other Names | SOS1, GINGF, NS4, SOS-1, Son of sevenless homolog 1, GF1, GGF1 |
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| Gene, Accession # | SOS1, Gene ID: 6654 |
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| Catalog # | LS-C188432 |
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| Price | |
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| Order / More Info | SOS1 Antibody from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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