| 产品详情 |
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| Product Name | PD 98059 |
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| Description | Purity >98%. PD 98059 is a noncompetitive inhibitor of the MAPK pathway. It prevents the activation of MEK by Raf or MEK kinase (a MAPKKK) with an IC50 value of 2-7 µM but does not inhibit Raf-activated MAPKK1. It inhibits Raf activation of MAPKK2 with an IC50 value of 50 µM. PD 98059 also phosphorylates and activates AMP-activated protein kinase (AMPK) in a dose-dependent manner (EC50 = 35 µM in HEK293 cells). It increases the ratios of ADP to ATP and AMP to ATP and increases phosphorylation of the AMPK target acetyl-CoA carboxylase (ACC). |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one, NSC 679828 |
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| Gene, Accession, CAS # | CAS: 167869-21-8 |
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| Catalog # | LS-H9299 |
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| Order / More Info | PD 98059 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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