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| Product Name | Human CD4 Protein (Recombinant) |
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| Description | Purity >95% by SDS-PAGE gel and HPLC analyses., MW: 41.3 kDa or 45-55 kDa. Cluster determinant 4 (CD4), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction and T-cell differentiation, development and activation. CD4 is constitutively expressed on the surface of various immune cells, including monocytes, macrophages, eosinophils, dendritic cells, and most prominently T lymphocytes, where it functions as an essential co-receptor and co-ligand for T-cell receptor (TCR) and major histocompatibility complex class II (MHC-II) molecules. Ligation by MHC-II molecules on the surface of antigen-presenting cells can serve to influence adaptive immunity by facilitating helper T-cell activation and macrophage differentiation, while ligation by proinflammatory cytokine IL-16 can contribute to innate immunity by chemoattracting CD4-expressing peripheral immune cells along an IL-16 gradient for their recruitment and activation at sites of inflammation. The protean functionality of CD4 extends past immunity as CD4 also notably serves as the major receptor for HIV-1 and human herpes virus 7 (HHV-7) infections. During HIV pathogenesis, CD4 acts instrumentally as a high-affinity entry receptor for the internalization of HIV-1 following binding of the viral envelope glycoprotein gp120 to CD4's extracellular domain. PeproTech'sCHO cell-derived Recombinant Human sCD4 is amonomeric glycoprotein of 371 amino acid residues, which correspond to the extracellular CD4 domain, and a calculated molecular weight of 41.3 kDa. As a result of glycosylation, Recombinant Human sCD4 migrates with an apparent molecular mass of approximately 45-55 kDa by SDS-Page Gel analysis, under reducing conditions. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CD4, CD4 antigen, CD4 receptor, CD4mut, CD4 antigen (p55), CD4 molecule |
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| Gene, Accession, CAS # | CD4, Gene ID: 920 |
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| Catalog # | LS-G133780 |
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| Order / More Info | Human CD4 Protein (Recombinant) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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