| 产品详情 |
| Edit |   |
|---|
| Product Name | LDE225 (phosphate) |
|---|
| Description | Purity >98%. Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of the GPCR-like receptor, Smoothened (SMO). In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers. LDE225 is an Hh signaling pathway inhibitor that acts by antagonizing SMO (IC50 s = 1.3 and 2.5 nM for mouse and human, respectively). A dose of 20 mg/kg/day LDE225 has been shown to penetrate the blood brain barrier, inhibit Gli1 mRNA expression, and prevent tumor growth in a medulloblastoma allograft mouse model. This compound has been investigated in phase II clinical trials for potential treatment of several Hh pathway activated cancers. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | rel -N-[6-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide, diphosphate, Erismodegib, NVP-LDE225, Sonidegib |
|---|
| Gene, Accession, CAS # | CAS: 1218778-77-8 |
|---|
| Catalog # | LS-H8432 |
|---|
| Price | |
|---|
| Order / More Info | LDE225 (phosphate) from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|