| 产品详情 |
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| Product Name | LDN-193189 (hydrochloride) |
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| Description | Purity >98%. LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are known as activin receptor-like kinases (ALKs), with an IC50 value of 4.9 nM. In in vitro kinase assays, it shows specificity for ALK1, 2, 3, and 6 (IC50 s = 0.8, 0.8, 5.3, and 16.7 nM, respectively) over ALK4 and 5 (IC50 s = 101 and 350 nM, respectively). LDN-193189 has been used to inhibit BMP type I receptor activity to study the pathogenesis of fibrodysplasia ossificans progressive, a congenital hyperossification disorder, and to examine the role of osteogenesis in prostate tumor metastases in bone. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline, monohydrochloride, DM-3189 |
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| Gene, Accession, CAS # | CAS: 1062368-62-0 |
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| Catalog # | LS-H8435 |
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| Order / More Info | LDN-193189 (hydrochloride) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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