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| Product Name | Seco Rapamycin (sodium salt) |
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| Description | Purity >85%. Rapamycin is a natural macrolide immunosuppressant that activates mTORC1. Seco Rapamycin (sodium salt) is a nonenzyme-dependent degradation product of rapamycin resulting from ester hydration followed by dehydration. It has less than 4% of the potency of rapamycin in a thymocyte proliferation assay. Rapamycin quickly degrades to two ring-opened products, including seco rapamycin, in the cytoplasm or in homogenates of Caco-2 cells. Like rapamycin, seco rapamycin is secreted from cells by P-glycoprotein and metabolized to a common dihydro species. While seco rapamycin poorly activates mTOR, it mimics rapamycin in its ability to inhibit the proteasome. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [2R-[2a,2(S*),3a,6β[2S*,3E,5E,7E,9S*,11R*,13R*,14R*,15E,7R*,19E,21R*,22(1S*,3R*,4R*)]]]-1-[oxo[tetrahydro-2-hydroxy-6-[14-hydroxy-22-(4-hydroxy-3methoxycyclohexyl)-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxo-3,5,7,15,19-docosapentaenyl]-3-methyl |
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| Gene, Accession, CAS # | CAS: 148554-65-8 |
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| Catalog # | LS-H9893 |
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| Order / More Info | Seco Rapamycin (sodium salt) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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